Reversal effect of Zhigancao decoction on myocardial fibrosis in a rapid pacing-induced atrial fibrillation model in New Zealand rabbits

Reversal effect of Zhigancao decoction on myocardial fibrosis in a rapid pacing-induced atrial fibrillation model in New Zealand rabbits

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Objective To evaluate the effect of Zhigancao decoction on reversal of right atrial myocardial fibrosis after rapid atrial pacing (RAP)-induced read more atrial fibrillation (AF).Methods New Zealand white rabbits were randomly divided into four groups: sham operation group (Group A: implanted electrodes, no RAP), pacing group (Group B: RAP-induced AF), Zhigancao soup water decoction Yin group (Group C: RAP-induced AF followed by Zhigancao soup Yin prescription twice a day for 30 days), and Zhigancao soup group (Group D: RAP-induced AF followed by Zhigancao water decoction twice a day for 30 days).The atrial myocardium was then examined for myocardial fibrosis by Masson staining, and protein expression of matrix metalloproteinase-9 (MMP-9) was immunohistochemically assessed.The right atrial appendage tissue field action potential duration (fAPD) was measured by microelectrode arrays.

Results RAP successfully induced AF.Myocardial fibrosis was more severe in Groups B and C and less severe in Group D.Protein expression of MMP-9 was strongly positive in Groups ventilationstejp B and C and weakly positive in Group D.The fAPD was significantly decreased in Groups B and C, but the decrease in Group D was not significant.

Conclusion Zhigancao decoction can reverse AF-induced myocardial fibrosis in rabbits and shorten the fAPD.